Cancer Epigenetics:

Projects in Dr. Singh lab are aimed at reducing the metastatic cancer deaths by pinpointing key common epigenetic drivers and rewired enhancers in Uveal Melanoma (UM) i.e. ocular tumor and other cancers with high metastatic instances e.g. high grade serous ovarian cancer (HGSOC). Also, Dr. Singh lab aims to validate new epigenetic therapeutic strategies using Zebrafish UM model and develop methods for early detection of metastasis using cell-free DNA.

Diseases Epigenetics:

Dr. Singh lab aims to decode the epigenomic/enhancer rewiring that drives Age-related macular degeneration (AMD) (that leads to vision loss) using human retinal organoid models by exploring the role of AMD-specific single-nucleotide polymorphisms (SNPs), inflammation drivers, epigenetic clock, histone variants and transcriptional reprogramming. As there are no therapeutics available for AMD, hence Dr. Singh lab using computational modeling of AMD epigenetic mechanisms and organoid models will develop drugs and potential therapies for AMD clinical application.